Research

12.061: Type I diabetes monitoring and QTc interval.

Diabetes mellitus (DM) is a common metabolic disorder characterised by high blood glucose. It is caused by a lack of pancreatic beta-cell insulin production in type 1 DM. Patients with type 1 diabetes mellitus have a seven-fold higher risk of sudden cardiac death than age-matched nondiabetic controls, although the underlying mechanism for this is unclear. Sudden cardiac death is closely linked with cardiac arrhythmia, particularly Torsades de Points (TdP) and prolongation of the QT interval is a key risk factor.

20.032: Type II diabetes monitoring and QTc interval.

Diabetes mellitus (DM) is a common metabolic disorder characterised by high blood glucose. It is caused by a reduced sensitivity of tissues to insulin in type 2 DM. Patients with type 2 diabetes mellitus may be at an increased risk of sudden cardiac death, hence this study. Sudden cardiac death is closely linked with cardiac arrhythmia, particularly Torsades de Points (TdP) and prolongation of the QT interval is a key risk factor.

19.030: Developing a non-invasive clinical tool to predict Non-Alcoholic Fatty Liver Disease (NAFLD) in clinical trial volunteers. 

NAFLD is a very common (25% of adults worldwide) and varied condition ranging from no symptoms to inflammation, scarring and cancer. In clinical trials it is important to detect fatty liver. Patients taking new medicines are monitored closely and carefully for the presence of any side-effects. Liver drug reactions are the 2^nd most common reason for stopping a trial. Fatty liver can confuse or worsen a drug reaction, so being able to detect this condition makes trials safer and more effective. The development of an artificial intelligence prediction tool is the focus of this study.